MSD’s legacy of antimicrobial innovation and action
Delivering on our commitment to fight infectious diseases for more than a century
October 12, 2023
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For more than 100 years, MSD has contributed to the discovery and development of novel medicines and vaccines to fight infectious diseases. With the growing burden of antimicrobial resistance (AMR), we’ve focused on stopping the increasing threat of AMR.
1930s
MSD Research Laboratories played a central role in the development of sulfas, the first synthetic antimicrobial.
1940s
In collaboration with Rutgers University, we developed streptomycin, the first antibiotic effective against tuberculosis. We also helped to develop one of the first methods for mass production of penicillin.
1950s & 1960s
We developed multiple novel methods to prevent infectious diseases, including pediatric vaccines.
1970s & 1980s
We received U.S. Food and Drug Administration (FDA) approval for two vaccines, as well as three antibiotics that treat a variety of bacterial infections.
1990s & 2000s
MSD received U.S. FDA approval for two antifungals, as well as licenses for two vaccines.
2002
With resistance to antibiotics developing faster through people, animals and the environment, we launched one of the world’s largest and longest-running antimicrobial resistance surveillance studies. Called the Study for Monitoring Antimicrobial Resistance Trends (SMART), the program enables researchers to monitor and identify trends in the development of AMR.
2010s
We launched an Antimicrobial Stewardship (AMS) Investigator Initiated Studies program, supporting investigator-based, peer-reviewed research supporting the implementation of AMS principles across the globe, with over 20% of studies occurring in low-and middle-income countries.
2016
We created the MSD Exploratory Science Center in Cambridge, Massachusetts, focusing on the earliest stages of research into the underlying biology of human disease.
2016-2017
We supported the first United Nations high-level meeting on AMR and subsequent political declaration in 2016, which set policy action on AMR in motion.
As a next step, we joined the newly founded AMR Industry Alliance – a network of over 100 pharmaceutical industry partners working to provide sustainable solutions to help curb antimicrobial resistance.
2020
MSD, along with a group of more than 20 leading biopharmaceutical companies, launched the AMR Action Fund to bring 2-4 new antibiotics to patients by the end of the decade.
2020s
Our staff have championed government actions to create supportive markets for antimicrobial innovation, including the PASTEUR Act in the U.S., inclusion of transferable exclusivity extensions in the EU pharmaceutical strategy, and other incentives around the world.
By collaborating with policymakers, MSD aims to improve appropriate antibiotic use globally.
Going forward
In recognition of our leadership in both human and animal health, MSD represents industry in the One Health Global Leaders Group on Antimicrobial Resistance, which advocates for a One Health approach to help ensure antibiotics remain an important tool in improving and maintaining human and animal health.
Listen as specialists from MSD discuss what they’re most excited about in researching potential treatments for neurologic disorders
July 13, 2023
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Our scientists are revolutionizing how we discover and develop treatments to address unmet medical needs in a number of areas, including neuroscience.
“It’s sort of like the final frontier,” said Joe Herring, scientific AVP, clinical research, in our new podcast. “You’re going off into space to try to figure out how to do very difficult things.”
For more, listen in as Herring sits down with MSD clinical research team senior principal scientists Yuki Mukai and Ari Merola as well as business development director Paige Lacatena to explore today’s breakthroughs and challenges in the field of neuroscience.
Individualized neoantigen therapies: exploring one medicine for one patient
Scientists are researching new ways to help train the immune system to fight cancer
April 13, 2023
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Over the past decade, immunotherapy has transformed our understanding of how the immune system can be used to help fight some types of cancer. However, for the last 50 years, scientists have been researching how we could potentially use vaccines to treat cancer — another investigational approach to harness the immune system to help recognize and destroy cancer cells — with little success.
Now we’re looking at a potential therapy that is building upon the learnings of immunotherapy trials from the past and incorporating that into an individualized cancer approach that’s specific to a patient’s own tumor. Researchers are currently exploring the potential of individualized neoantigen therapies to help fight cancer.
Cancer research is becoming more personalized
Cancer is a result of the body’s own cells undergoing mutations which create abnormal proteins in cancer cells, known as neoantigens, that are not usually seen in normal cells. These mutations are unique to each person’s tumor, so that’s one of the reasons why patients who have been diagnosed with the same type of cancer and who have received the same type of treatment may have different responses.
As the treatment of cancer continues to evolve and advance, researchers are focusing on more individualized approaches. This includes a new area of research into individualized neoantigen therapies that use information from a person’s tumor biopsy sample to help develop a therapy unique to their tumor’s mutations.
“This area of research has really captured our imagination of what’s possible in the development of cancer therapeutics.”
Dr. Jane Healy Vice president and head of oncology early development at MSD Research Laboratories
In collaboration with Moderna, we’re studying this area of research in an effort to advance more individualized approaches to help improve outcomes for people living with cancer.
Learn more about individualized neoantigen therapies
Our commitment to HIV treatments and prevention through the years
We continue to work at the forefront of the fight against HIV
March 15, 2021
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HIV (human immunodeficiency virus) continues to be a major public health threat. The virus can lead to AIDS.
Since 1985, our company has been engaged in research and development efforts in the prevention and treatment of HIV. Over the years, our scientists have made significant discoveries that changed the way HIV is treated. Here are some historical moments highlighting this effort:
In 1982, the U.S. Centers for Disease Control and Prevention first used the term “AIDS,” or acquired immune deficiency syndrome, to describe the clinical syndrome caused by the human immunodeficiency virus (HIV).
In the mid-1980s, MSD launched its HIV research program in response to what it perceived as a potential epidemic. Our scientists were among the first to discover and develop medicines for the treatment of HIV.
We were the first to publish the crystal structure of HIV protease, which is an enzyme which is essential for virus infectivity.
In 1992, MSD joined other pharmaceutical companies to create the Inter-Company Collaboration for AIDS Drug Development to research HIV treatments. By 1993, we were undertaking the biggest research program in our history, deploying more scientists to investigate AIDS than any other disease and testing tens of thousands of compounds.
The HIV/AIDS community continued to speak out for action. In 1995, Linda Distlerath, former executive director, Public Policy and MSD Research Laboratories Public Affairs, spent time reading letters sent from thousands of AIDS patients and activists urging MSD to produce a treatment for the disease quickly.
After years of study and development, MSD developed one of the first protease inhibitors. In 1995, prior to FDA approval, in conjunction with the U.S. Food and Drug Administration, patients and HIV advocacy groups, MSD offered a program that made its new HIV treatment available at no cost to selective patients before it was commercially available.
In 1996, the HIV treatment received FDA approval in a record-setting 42 days. It was an important early achievement in making HIV a survivable infection.
In 2012, The NAMES Project Foundation – with support from MSD – launched Call My Name national tour to bring attention to the distressing trajectory of the HIV epidemic in the Black communities in the U.S. The tour included creating new panels for the AIDS memorial quilt and educational workshops in 10 high-prevalence cities.
In 2021, we entered into an agreement with Gilead to work together in the global HIV community in the fight against HIV.
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