Innovation

Podcast: How AI can improve insight into disease biology

A scientist explains how we’re using AI capabilities to help identify patterns in tissue and tumor samples indiscernible to the human eye

December 20, 2024

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We see the potential of data science, artificial intelligence (AI) and machine learning (ML) to help investigate new areas, pathways and mechanisms that may forge new opportunities to strengthen our pipeline through enhanced insights.

In a recent episode of the Health Pulse podcast by SAS, Dr. Greg Goldmacher, associate vice president, clinical research, and head of clinical imaging and pathology at MSD, discussed how we’re using these AI capabilities, like computer vision, to improve disease biology insights and help with objective imaging analysis to identify patterns indiscernible to the human eye.

“If you have AI tools that are trained to pick up subtle early signs of disease on scans that are being done for other reasons, there’s a real opportunity there for earlier diagnosis,” said Goldmacher in the podcast episode. “If you’re going to do opportunistic screening, for example, and want to train AI for that, what you need is longitudinal data sets where you can find patients who had the disease, and then go and look for scans that they might have had in the past to use to train the disease-recognizing models.”

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Innovation

TL1A: Exploring a potentially important target for inflammatory bowel disease

Our scientists are investigating ways to modulate TL1A to potentially address inflammation and fibrosis associated with inflammatory bowel disease

October 9, 2024

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Picture the immune system as a carefully orchestrated network of organs, cells and molecules working together to protect your body from foreign invaders. Normally, this system operates smoothly, identifying and then fighting off microbes. However, in the case of inflammatory bowel disease (IBD), a person’s immune system can mistakenly attack their own tissues, causing chronic inflammation and tissue damage.

Approximately 10 million people live with IBD worldwide, the two most common forms being Crohn’s disease and ulcerative colitis. Patients with IBD experience symptoms such as diarrhea, blood in the stool, abdominal pain, unintended weight loss, fatigue and impaired sleep. In 25-40% of patients, IBD may affect organs and tissues outside of the gastrointestinal system, including the joints, skin, bones, eyes, kidneys and liver. When IBD is uncontrolled, it can lead to hospitalizations and surgery.

Despite available therapies which have helped improve patients’ symptoms over the last two decades, many patients do not achieve a state of sustained remission.  

“People with IBD often struggle to find a treatment that works for them because each individual’s disease is different,” said Aileen Pangan, vice president and therapeutic area head, immunology clinical research, MSD Research Laboratories.

“With a better understanding of the biology of IBD, medicines have begun to emerge that aim to change the way we approach treatment. We’re investigating ways to modulate targets, including TL1A, that have been implicated in IBD and other immune-mediated inflammatory diseases.”

• Aileen Pangan

Our TL1A research

Our scientists are investigating tumor necrosis factor-like ligand 1A (TL1A), which has been shown to be increased in inflamed intestinal tissue and in the systemic circulation of patients with IBD.

TL1A is a cytokine, a protein functioning as a chemical messenger, that acts as a regulator of cellular immunity. In healthy people, levels of TL1A increase to help immune cells fight infections effectively, with levels going back down after the infection is gone. However, in IBD, TL1A levels are chronically elevated, leading to an excessive buildup of immune cells in the digestive tract, chronic inflammation, tissue damage and fibrosis.

Teams at MSD are evaluating the potential role of TL1A across immune-mediated inflammatory diseases, including Crohn’s disease, ulcerative colitis and systemic sclerosis-associated interstitial lung disease (SSc-ILD). Learn more about our research in immunology.

Innovation

What is One Pipeline?

How we’re advancing the best internal and external science to progress our pipeline for patients

May 30, 2024

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Drug development is a long and difficult endeavor. It can take more than 10 years to bring a new medicine to market. So how does our company think about developing new medicines and vaccines to help save and improve lives? The answer: through our One Pipeline strategy, where we complement our internal innovation and discovery efforts with the best external science through business development.

“Our One Pipeline strategy enables us to advance breakthrough science, whether it comes from our own labs or from our partners’ labs, and make medicines and vaccines for patients,” said Dr. Dean Li, president, MSD Research Laboratories (MRL). “Every day, we’re pushing scientific boundaries in research. Business development and external partnerships are integral to help drive our internal pipeline and to provide access to assets that are important for our discovery and clinical development groups.”

To achieve that balance, MRL works in lockstep with our business development and licensing (BD&L) team. “I want to emphasize how integrated BD&L is with MRL. This is hand in glove,” said Li.

Business development augments our pipeline

Our BD&L team is committed to securing scientific and commercial collaborations, licensing agreements and acquisitions from discovery to late-stage candidates and new technologies to help build our robust portfolio. We have a legacy of successful collaborations and are among the most active dealmakers in the biopharma industry.

“We match our strong scientific conviction with bold investments in novel, cutting-edge science to advance new options for patients,” said Sunil Patel, senior vice president, head of corporate development and BD&L. “We’re focused on bringing in the best external science to complement our internal efforts to deliver on our purpose and sustain our company for the next 130 years.”

The BD&L team members focused on our pipeline are embedded with scientists across our research network and, in addition to our New Jersey and Pennsylvania sites, they’re strategically located in key epicenters of innovation including Boston, Cambridge, London, South San Francisco, Shanghai and Tokyo. The team searches the globe for cutting-edge science and works alongside our research team to evaluate opportunities built on strong scientific principles, regardless of location or origin.

Creating a sustainable innovation engine

As part of our One Pipeline strategy, we ensure a smooth transition when bringing in external science and leverage our clinical development and manufacturing expertise to advance each program with speed and rigor. This strategy is helping to build and maintain the flow of novel candidates through clinical development to patients, enabling long-term, sustainable growth for our company.

“Strategic business development focused on the best external science remains an important priority for our company. We’ve demonstrated that we can leverage our deep discovery prowess to identify important acquisition targets and then add significant value through our powerful clinical research engine, our regulatory expertise and our commercial scale, which together can serve to accelerate development and enable broad global access to important medical discoveries for patients in need,” said Rob Davis, chairman and chief executive officer.

Pipeline

We’re focused on discovering new medicines and vaccines for today and the future. View our pipeline.

Business development and licensing

We work with many partners, from early-stage science to clinical-stage programs, to deliver life-changing therapies.